This safety instruction points out some important aspects for the safe handling of hazardous substances which may endanger health. In particular, the lessons describe basic occupational hygiene measures and complement the safety instructions on the topic of “Handling hazardous substances". The training tool is intended to assist managers for the personal instruction of employees and to start an open discussion on the topic of occupational safety. The safety briefing set enables superiors to share their knowledge about safe working to their subordinates and colleagues, especially with vulnerable groups.